Days to weeks for significant mucociliary clearance improvement
Duration
Sustained with daily use
Mechanism of action
Recombinant human DNase I enzyme. Cleaves extracellular DNA (from neutrophil breakdown) that contributes to the viscosity of CF sputum. Reduces sputum viscoelasticity without affecting mucin or disulfide bonds.
Dosing
Adult
SVN: 2.5 mg (1 ampule) once daily via recommended nebulizer systems
Pediatric
≥5 years: 2.5 mg once daily. Some patients may benefit from BID dosing
Indications
Cystic fibrosis (management of thick secretions)
May be used in non-CF bronchiectasis (off-label)
Contraindications
Hypersensitivity to dornase alfa or Chinese Hamster Ovary cell products