Calfactant

Mechanism of action

Natural bovine lung surfactant extract. Contains phospholipids and surfactant proteins SP-B and SP-C. Reduces alveolar surface tension to near-zero during expiration, preventing end-expiratory alveolar collapse.

Dosing

Neonatal

3 mL/kg intratracheally (105 mg phospholipids/kg). May repeat q12h × 3 doses